Kunming Shao

Kunming Shao

Purdue University
Immunology/Immunotherapy
Ph.D. Candidate

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The Art of Fly Fishing: A Journey into Nature and Skill

3 minute read

Published:

Fly fishing is more than just a method of catching fish; it’s an art form that connects the angler deeply with nature. Unlike conventional fishing, fly fishing uses lightweight, artificial flies that mimic the insects and other small creatures fish naturally feed on. This technique requires a unique casting method where the angler must skillfully manipulate the line to present the fly in a way that mimics the natural movement of prey.

portfolio

publications

A comprehensive single cell data analysis of lymphoblastoid cells reveals the role of super‐enhancers in maintaining EBV latency

Published in Journal of Medical Virology, 2022

This study delves into the lifecycle of Epstein-Barr virus (EBV) using single-cell RNA sequencing data from nine lymphoblastoid cell lines (LCLs). While most cells were in the latent phase, two distinct clusters emerged, characterized by the high expression of EBV genes LMP1/BNLF2 and BZLF1.

Recommended citation: Yan B, Wang C, Chakravorty S, et al. A comprehensive single cell data analysis of lymphoblastoid cells reveals the role of super-enhancers in maintaining EBV latency. J Med Virol. 2022;95:e28362. https://doi.org/10.1002/jmv.28362

Inwardly rectifying potassium channels regulate direction sensing during neutrophil chemotaxis

Published in Journal of Cell Biology (JCB), 2025

We demonstrate that the inwardly rectifying potassium channel Kir7.1 is essential for directional sensing during neutrophil chemotaxis, influencing membrane potential dynamics and GPCR signaling.

Recommended citation: Dr. Tianqi Wang, Mr. Daniel H Kim, Ms. Chang Ding, Mr. Dingxun Wang, Dr. Weiwei Zhang, Dr. Martin Silic, Dr. Xi Cheng, Mr. Kunming Shao, Mr. TingHsuan Ku, Mr. Conwy Zheng, Dr. Junkai Xie, Dr. Chongli Yuan, Dr. Alexander A Chubykin, Prof. Christopher J Staiger, Dr. Guangjun Zhang. Inwardly rectifying potassium channels regulate direction sensing during neutrophil chemotaxis. Journal of Cell Biology 2025. https://doi.org/10.1083/jcb.202503037

scChat: A large language model‐powered co‐pilot for contextualized single‐cell RNA sequencing analysis

Published in American Institute of Chemical Engineers (AIChE), 2026

We introduce scChat, a pioneering AI assistant designed for contextualized scRNA-seq analysis. Unlike existing tools that focus on standard tasks like cell annotation, scChat offers advanced capabilities, including research context-based analysis of experimental outcomes and suggestions for next-step experimental design.

Recommended citation: Chiu H-H, Varghese A, Shao K, et al. scChat: A large language model-powered co-pilot for contextualized single-cell RNA sequencing analysis. AIChE J. 2026;e70285. https://doi.org/10.1002/aic.70285

Photo-click Decellularized Matrix Hydrogels for Generating Pancreatic Ductal Organoids

Published in bioRxiv, 2026

We demonstrate that photo-clickable dSIS–norbornene (dSIS-NB) hydrogels can replace Matrigel to generate human iPSC-derived pancreatic ductal organoids, and that matrix stiffness is a key determinant of ductal fate.

Recommended citation: Hgoc Ha Luong, Kunming Shao, Van Thuy Duong, Xiaoping Bao, Chien-Chi Lin, bioRxiv 2026.02.16.706185 https://www.biorxiv.org/content/10.64898/2026.02.16.706185v1

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