Publications

Photo-click Decellularized Matrix Hydrogels for Generating Pancreatic Ductal Organoids

Published in bioRxiv, 2026

We demonstrate that photo-clickable dSIS–norbornene (dSIS-NB) hydrogels can replace Matrigel to generate human iPSC-derived pancreatic ductal organoids, and that matrix stiffness is a key determinant of ductal fate.

Recommended citation: Hgoc Ha Luong, Kunming Shao, Van Thuy Duong, Xiaoping Bao, Chien-Chi Lin, bioRxiv 2026.02.16.706185 https://www.biorxiv.org/content/10.64898/2026.02.16.706185v1

scChat: A large language model‐powered co‐pilot for contextualized single‐cell RNA sequencing analysis

Published in American Institute of Chemical Engineers (AIChE), 2026

We introduce scChat, a pioneering AI assistant designed for contextualized scRNA-seq analysis. Unlike existing tools that focus on standard tasks like cell annotation, scChat offers advanced capabilities, including research context-based analysis of experimental outcomes and suggestions for next-step experimental design.

Recommended citation: Chiu H-H, Varghese A, Shao K, et al. scChat: A large language model-powered co-pilot for contextualized single-cell RNA sequencing analysis. AIChE J. 2026;e70285. https://doi.org/10.1002/aic.70285

Inwardly rectifying potassium channels regulate direction sensing during neutrophil chemotaxis

Published in Journal of Cell Biology (JCB), 2025

We demonstrate that the inwardly rectifying potassium channel Kir7.1 is essential for directional sensing during neutrophil chemotaxis, influencing membrane potential dynamics and GPCR signaling.

Recommended citation: Dr. Tianqi Wang, Mr. Daniel H Kim, Ms. Chang Ding, Mr. Dingxun Wang, Dr. Weiwei Zhang, Dr. Martin Silic, Dr. Xi Cheng, Mr. Kunming Shao, Mr. TingHsuan Ku, Mr. Conwy Zheng, Dr. Junkai Xie, Dr. Chongli Yuan, Dr. Alexander A Chubykin, Prof. Christopher J Staiger, Dr. Guangjun Zhang. Inwardly rectifying potassium channels regulate direction sensing during neutrophil chemotaxis. Journal of Cell Biology 2025. https://doi.org/10.1083/jcb.202503037

A comprehensive single cell data analysis of lymphoblastoid cells reveals the role of super‐enhancers in maintaining EBV latency

Published in Journal of Medical Virology, 2022

This study delves into the lifecycle of Epstein-Barr virus (EBV) using single-cell RNA sequencing data from nine lymphoblastoid cell lines (LCLs). While most cells were in the latent phase, two distinct clusters emerged, characterized by the high expression of EBV genes LMP1/BNLF2 and BZLF1.

Recommended citation: Yan B, Wang C, Chakravorty S, et al. A comprehensive single cell data analysis of lymphoblastoid cells reveals the role of super-enhancers in maintaining EBV latency. J Med Virol. 2022;95:e28362. https://doi.org/10.1002/jmv.28362